The National Football League has arrived. The games are ready to rock and roll.
The teams are getting their final preparations ready, and the action will be hot and heavy starting Thursday night. Then, the big Sunday slate hits, followed by Monday Night Football.
Let’s look at a few of our favorite games in Week 1. Here is a look at our Top 5 NFL Week 1 Against the Spread Picks.
NFL Week 1 ATS Picks | MyBookie Regular Season Preview
2023-24 NFL | 104th season of the National Football League
Regular Season: September 7, 2023 – January 7, 2024
Kansas City Chiefs vs. Detroit Lions | Thursday Night Football
ATS: -6.5
Thursday, September 7th, 2023 | NBC
GEHA Field at Arrowhead Stadium, Kansas City, MO
The defending Super Bowl Champions get the party started for Week 1 of the National Football League. This should be an excellent opportunity to get it going in Kansas City. Patrick Mahomes and company will get the banner raised, then put the Lions in their place early in the season.
Many folks are all over Detroit to compete and be an NFC contender. Before that, they must show they can hang with the big dogs. This game could have gone better for them. The Kansas City Chiefs win by 10+ in this game over the Detroit Lions on Thursday.
NFL Week 1 ATS Pick: -6.5 | Bet Chiefs at Lions
MyBookie Betting Lines for the Total
Chicago Bears vs. Green Bay Packers | NFC North Rivalry Game
ATS: -1
Sunday, September 10th, 2023 at 4:25 pm | CBS
Empower Field at Mile High, Denver, CO
A huge NFC North rivalry game. The Chicago Bears are at home against the Green Bay Packers. Justin Fields and company look to have a new roster ready to compete.
This is Year 3 for Fields, so many expect him to pick up his game. Several have put his name into the talk for National Football League Most Valuable Player.
Not sure we can go that far, but Fields and the Bears are better than Love and the Packers in this one. Look for Chicago to be rocking as they get a chance to beat a rivalry they rarely beat. Bears win this game at home.
NFL Week 1 ATS Pick: -1 | Bet Bears at Packers
MyBookie Betting Lines for the Total
Seattle Seahawks vs. Los Angeles Rams
ATS: -5.5
Sunday, September 10th, 2023 at 4:25 pm | FOX
Lumen Field, Seattle, WA
No Cooper Kupp will be a big-time problem for the Los Angeles Rams. Matthew Stafford has not been happy about the preseason, and that will boil over into the regular season.
The Seattle Seahawks were a fun team to watch a season ago, with Geno Smith playing good football. Do not be surprised if they start hot here. The Seahawks win this game and cover the spread at home over the Rams.
NFL Week 1 ATS Pick: -5.5 | Bet Seahawks at Rams
MyBookie Betting Lines for the Total
Jacksonville Jaguars at Indianapolis Colts
ATS: -5
Sunday, September 10th, 2023 at 1:00 pm | FOX
Lucas Oil Stadium, Indianapolis, IN
Trevor Lawrence and the Jacksonville Jaguars won a postseason game a season ago. People need to remember that when they are talking about the 2023 Jaguars. That team will be a season more experienced. This is going to be a fun team to follow.
On the other side, the Colts are an absolute mess. The Jonathan Taylor thing is terrible for the team and will not bode well in the win column. An already bad team got worse. Take the Jaguars to win this game on the road over the Colts.
NFL Week 1 ATS Pick: -5 | Bet Jaguars at Colts
MyBookie Betting Lines for the Total
Buffalo Bills at New York Jets | Monday Night Football
ATS: -2.5
Monday, September 11th, 2023 at 8:15 pm | ESPN, ESPN+, ABC
MetLife Stadium, East Rutherford, NJ
The final game of the Week 1 slate. Monday Night Football Live from the Meadowlands. The hype on this game is going to be out of control. Josh Allen and his Bills invade Aaron Rodgers and his new team – the Jets.
The Jets are getting much love with talk of them taking over the division. This would be a great start to that. But – not so sure it’s going actually to happen. Take the Buffalo Bills with their talent to win this game on the road. Buffalo -2.5!
NFL Week 1 ATS Pick: -2.5 | Bet Bills at Jets
MyBookie Betting Lines for the Total
NFL Week 1 Schedule
Dates: 9/7 – 9/11
BYE WEEK: No teams on bye
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Sept. 7 | Lions at Chiefs (-7) | Lions +232; Chiefs -300 | 54 |
Sun, Sept. 10 |
Texans at Ravens (-9.5) | Texans +330; Ravens -450 |
44.5 |
Sun, Sept. 10 |
Buccaneers at Vikings (-6.5) | Buccaneers +235; Vikings -300 |
45.5 |
Sun, Sept. 10 |
Bengals (-2.5) at Browns | Bengals -136; Browns +111 |
47 |
Sun, Sept. 10 |
Jaguars (-3) at Colts | Jaguars -172; Colts +140 | 43.5 |
Sun, Sept. 10 |
49ers (-3) at Steelers | 49ers -160; Steelers +130 | 40.5 |
Sun, Sept. 10 |
Cardinals at Commanders (-5.5) | Cardinals +204; Commanders -259 | 40.5 |
Sun, Sept. 10 |
Titans at Saints (-3.5) | Titans +150; Saints -185 | 41.5 |
Sun, Sept. 10 |
Panthers at Falcons (-3) | Panthers +132; Falcons -162 | 42.5 |
Sun, Sept. 10 |
Eagles (-4.5) at Patriots | Eagles -204; Patriots +164 | 45 |
Sun, Sept. 10 |
Dolphins at Chargers (-2.5) | Dolphins +115; Chargers -141 | 50 |
Sun, Sept. 10 |
Packers at Bears (-2.5) | Packers +114; Bears -139 | 44 |
Sun, Sept. 10 |
Rams at Seahawks (-5) | Rams +185; Seahawks -232 | 47 |
Sun, Sept. 10 |
Raiders at Broncos (-3.5) | Raiders +157; Broncos -194 | 44.5 |
Sun, Sept. 10 |
Cowboys (-3) at Giants | Cowboys -168; Giants +136 | 46.5 |
Mon, Sept. 11 |
Bills (-1.5) at Jets | Bills -121; Jets +100 | 47 |
NFL Week Two >>
The following NFL betting odds are based on MyBookie Sportsbook.
Super Bowl Odds to Win this 2025 NFL Season
| Teams | Odds |
|---|---|
| San Francisco 49ers | +550 |
| Kansas City Chiefs | +700 |
| Baltimore Ravens | +800 |
| Buffalo Bills | +1000 |
| Detroit Lions+1200 | |
| Cincinnati Bengals | +1300 |
| Dallas Cowboys | +1600 |
| Philadelphia Eagles | +1800 |
| Miami Dolphins | +2000 |
| Green Bay Packers | +2200 |
| Houston Texans | +2200 |
| LA Chargers | +2500 |
| New York Jets | +2500 |
| Jacksonville Jaguars | +3500 |
| Los Angeles Rams | +3500 |
| Cleveland Browns | +4000 |
| Minnesota Vikings | +4000 |
| Atlanta Falcons | +5000 |
| Chicago Bears | +5000 |
| Indianapolis Colts | +5000 |
| Denver Broncos | +7500 |
| Las Vegas Raiders | +7500 |
| New Orleans Saints | +7500 |
| Pittsburgh Steelers | +7500 |
| Seattle Seahawks | +7500 |
| Tampa Bay Buccaneers | +7500 |
| Arizona Cardinals | +10000 |
| New England Patriots | +15000 |
| New York Giants | +15000 |
| Tennessee Titans | +15000 |
| Washington Commanders | +15000 |
| Carolina Panthers | +25000 |
There you go. Those are our five favorite Week 1 Against the Spread Picks in the National Football League. We hope you enjoyed them and will get some bets in before the season kicks off. Best of luck, and enjoy the games!
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