Explore the NFL top betting Week 5 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
This Week, our experts decide to include for you a 3-Step Formula if you want to start thinking in Super Bowl prop betting.
NFL Football Lines Week Five
Top NFL Week 5 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 5: Thursday, October 2nd – Monday, October 6th, 2025
BYE WEEK: Falcons, Bears, Packers, Steelers
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NFL Football Lines Week Five
Betting 2025 NFL Week 5 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Oct 2 – Totals 46.5
49ers Spread -7, Winner +257
Rams Spread +6, Winner -336
Oct 5 – Totals O/U 36
Vikings Spread -3.5, Winner -234
Browns Spread +3.5, Winner +179
Oct 5 – Totals 44.5
Dolphins Spread -1, Winner -118
Panthers Spread +1, Winner -108
Oct 5 – Totals 48
Raiders Spread +7, Winner +232
Colts Spread -7, Winner -319
Oct 5 – Totals 41
Giants Spread +2.5, Winner +104
Saints Spread -2.5, Winner -132
Oct 5 – Totals O/U 43.5
Broncos Spread +4, Winner +163
Eagles Spread -4, Winner -212
Oct 5 – Totals O/U 47.5
Cowboys Spread -2.5, Winner -148
Jets Spread +2.5, Winner +116
Oct 5 – Totals O/U 40.5
Texans Spread -1.5, Winner -127
Ravens Spread +1.5, Winner +100
Oct 5 – Totals O/U 41.5
Titans Spread +7.5, Winner +316
Cardinals Spread -7.5, Winner -463
Oct 5 – Totals O/U 44.5
Buccaneers Spread +3.5, Winner +147
Seahawks Spread -3.5, Winner -189
Oct 5 – Totals O/U 49.5
Lions Spread -10, Winner -594
Bengals Spread +10, Winner +389
Oct 5 – Totals O/U 48
Commanders Spread +3, Winner +129
Chargers Spread -3, Winner -166
Oct 5 – Totals O/U 49.5
Patriots Spread +7.5, Winner +298
Bills Spread -7.5, Winner -424
Oct 6 – Totals O/U 46.5
Chiefs Spread -3, Winner -189
Jaguars Spread +3, Winner +147
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
