Explore the NFL top betting Week 16 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Sixteen
Top NFL Week 16 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 16: Thursday, December 18th – Monday, December 22nd, 2025
BYE WEEK: No teams on bye.
Key Games to Watch and Bet
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NFL Football Lines Week Sixteen
Betting 2025 NFL Week 16 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
| Date | Spread | Moneyline | Over Under |
|---|---|---|---|
| Thu, Dec. 18, 8:15 PM EST | Rams at Seahawks | Rams TBA; Seahawks TBA | TBA |
| Sun. Dec. 21, 1:00 PM EST | Patriots vs Ravens | Patriots TBA; Ravens TBA | TBA |
| Sun, Dec. 21, 1:00 PM EST | Buccaneers at Panthers | Buccaneers TBA; Panthers TBA | TBA |
| Sun. Dec. 21, 1:00 PM EST | Bills at Browns | Bills TBA; Browns TBA | TBA |
| Sun. Dec. 21, 1:00 PM EST | Chargers at Cowboys | Chargers TBA; Cowboys TBA | TBA |
| Sun, Dec. 21, 1:00 PM EST | Jets at Saints | Jets TBA; Saints TBA | TBA |
| Sun. Dec. 21, 1:00 PM EST | Vikings at Giants | Vikings TBA; Giants TBA | TBA |
| Sun, Dec. 21, 1:00 PM EST | Chiefs at Titans | Chiefs TBA; Titans TBA | TBA |
| Sun. Dec. 21, 4:05 PM EST | Falcons at Cardinals | Falcons TBA; Cardinals TBA | TBA |
| Sun, Dec. 21, 4:05 PM EST | Jaguars at Broncos | Jaguars TBA; Broncos TBA | TBA |
| Sun. Dec. 21, 4:25 PM EST | Steelers at Lions | Steelers TBA; Lions TBA | TBA |
| Sun, Dec. 21, 4:25 PM EST | Raiders at Texans | Raiders TBA; Texans TBA | TBA |
| Sun. Dec. 21, 8:20 PM EST | Bengals at Dolphins | Bengals TBA; Dolphins TBA | TBA |
| Mon, Dec. 21, 8:15 PM EST | 49ers at Colts | 49ers TBA; Colts TBA | TBA |
| TBD | Packers at Bears | Packers TBA; Bears TBA | TBA |
| TBD | Eagles at Commanders | Eagles TBA; Commanders TBA | TBA |
<< Week Fifteen
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
