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NFL Football Lines Week One
Top NFL Week 1 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 1: Thursday, September 4th – Monday, September 8th, 2025
BYE WEEK: No teams on bye
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NFL Football Lines Week One
Betting 2025 NFL Week 1 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Sep 4 – Totals O/U 47.5
Eagles Spread -8.5, Winner -410
Cowboys Spread +8.5, Winner +310
Sep 5 – Totals O/U 46
Chargers Spread +3, Winner +141
Chiefs Spread -3, Winner -175
Sep 7 – Totals O/U 46.5
Colts Spread -1, Winner -114
Dolphins Spread +1, Winner -107
Sep 7 – Totals 38.5
Jets Spread +3, Winner +124
Steelers Spread -3, Winner -152
Sep 7 – Totals 46
Commanders Spread -6, Winner -285
Giants Spread +6, Winner +222
Sep 7 – Totals 47.5
Falcons Spread +2, Winner +114
Buccaneers Spread -2, Winner -139
Sep 7 – Totals 43
Saints Spread +6.5, Winner +240
Cardinals Spread -6.5, Winner -310
Sep 7 – Totals 47.5
Browns Spread +5, Winner +181
Bengals Spread -5, Winner -226
Sep 7 – Totals O/U 47
Jaguars Spread -3.5, Winner -188
Panthers Spread +3.5, Winner +152
Sep 7 – Totals O/U 43.5
Patriots Spread -2.5, Winner -143
Raiders Spread +2.5, Winner +117
Sep 7 – Totals O/U 42.5
Broncos Spread -8, Winner -429
Titans Spread +8, Winner +320
Sep 7 – Totals O/U 43
Seahawks Spread +2, Winner +109
49ers Spread -2, Winner -134
Sep 7 – Totals O/U 44
Rams Spread -3, Winner -160
Texans Spread +3, Winner +130
Sep 7 – Totals O/U 47.5
Packers Spread -2, Winner -142
Lions Spread +2, Winner +116
Sep 7 – Totals O/U 50.5
Bills Spread +1, Winner -106
Ravens Spread -1, Winner -115
Sep 8 – Totals O/U 44
Bears Spread +1.5, Winner +100
Vikings Spread -1.5, Winner -122
NFL Week Two >>
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NFL WEEK 1 RISK FREE PARLAY BET
— MyBookie – Bet With The Best (@MyBookie) August 8, 2025
Cowboys vs Eagles O 46.5
Chiefs vs Chargers O 45.5
Ravens vs Bills O 51.5
Vikings vs Bears O 44.5
REFUND IF LOSS
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
