Let’s see the NFL top betting Week 4 odds at MyBookie for insights, strategies and updates to enhance your game day experience.
NFL Football Lines Week Four
Top NFL Week 4 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 4: Thursday, September 25th – Monday, September 29th, 2025
BYE WEEK: No teams on bye
Must-Watch Matchups to Secure your Bets
So, what are you waiting for?
Head over to our NFL betting lines now and Sign Up for an Account to bet on all the matchups of Week 4 and the rest of the season, you’re sure to find the perfect wager to add some extra excitement to your NFL viewing experience!
NFL Football Lines Week Four
Betting 2025 NFL Week 4 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Sep 25 – Totals TBA
Seahawks Spread TBA, Winner TBA
Cardinals Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Vikings Spread TBA, Winner TBA
Steelers Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Commanders Spread TBA, Winner TBA
Falcons Spread TBA, Winner TBA
Sep 28 – Totals TBA
Saints Spread TBA, Winner TBA
Bills Spread TBA, Winner TBA
Sep 28 – Totals TBA
Browns Spread TBA, Winner TBA
Lions Spread TBA, Winner TBA
Sep 28 – Totals TBA
Titans Spread TBA, Winner TBA
Texans Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Panthers Spread TBA, Winner TBA
Patriots Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Chargers Spread TBA, Winner TBA
Giants Spread TBA, Winner TBA
Sep 28 – Totals O/U 48.5
Eagles Spread -2.5, Winner -152
Buccaneers Spread +2.5, Winner +119
Sep 28 – Totals O/U TBA
Colts Spread TBA, Winner TBA
Rams Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Jaguars Spread TBA, Winner TBA
49ers Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Ravens Spread TBA, Winner TBA
Chiefs Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Bears Spread TBA, Winner TBA
Raiders Spread TBA, Winner TBA
Sep 28 – Totals O/U TBA
Packers Spread TBA, Winner TBA
Cowboys Spread TBA, Winner TBA
Sep 29 – Totals O/U TBA
Jets Spread TBA, Winner TBA
Dolphins Spread TBA, Winner TBA
Sep 29 – Totals O/U TBA
Bengals Spread TBA, Winner TBA
Broncos Spread TBA, Winner TBA
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About the Author
- D.S. Williamson
- Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
