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Let’s see the NFL top betting Week 4 odds at MyBookie for insights, strategies and updates to enhance your game day experience. Our writers are back with their best bets and predictions for every matchup.
NFL Football Lines Week Four
Top NFL Week 4 Matchups to Watch
2025 NFL Season | 106th season of the National Football League
Week 4: Thursday, September 25th – Monday, September 29th, 2025
BYE WEEK: No teams on bye
Must-Watch Matchups to Secure your Bets
So, what are you waiting for?
Head over to our NFL betting lines now and Sign Up for an Account to bet on all the matchups of Week 4 and the rest of the season, you’re sure to find the perfect wager to add some extra excitement to your NFL viewing experience!
NFL Football Lines Week Four
Betting 2025 NFL Week 4 Calendar Odds | Spread, Moneyline and Totals for the Matchups
Odds Subject to Change
Sep 25 – Totals O/U 43.5
Seahawks Spread -1.5, Winner -122
Cardinals Spread +1.5, Winner +100
Sep 28 – Totals O/U 41
Vikings Spread -2.5, Winner -152
Steelers Spread +2.5, Winner +119
Sep 28 – Totals O/U 45
Commanders Spread -1, Winner -121
Falcons Spread +1, Winner -105
Sep 28 – Totals O/U 48
Saints Spread +16.5, Winner +788
Bills Spread -16.5, Winner -1683
Sep 28 – Totals O/U 44
Browns Spread +9.5, Winner +351
Lions Spread -9.5, Winner -536
Sep 28 – Totals O/U 38.5
Titans Spread +7, Winner +295
Texans Spread -7, Winner -420
Sep 28 – Totals O/U 43
Panthers Spread +5.5, Winner +188
Patriots Spread -5.5, Winner -248
Sep 28 – Totals O/U 44
Chargers Spread -6.5, Winner -290
Giants Spread +6.5, Winner +216
Sep 28 – Totals O/U 43.5
Eagles Spread -3.5, Winner -200
Buccaneers Spread +3.5, Winner +154
Sep 28 – Totals O/U 49.5
Colts Spread +3.5, Winner +149
Rams Spread -3.5, Winner -193
Sep 28 – Totals O/U 47
Jaguars Spread +3, Winner +138
49ers Spread -3, Winner -178
Sep 28 – Totals O/U 48.5
Ravens Spread -3, Winner -152
Chiefs Spread +3, Winner +119
Sep 28 – Totals O/U 48
Bears Spread +1, Winner -111
Raiders Spread -1, Winner -114
Sep 28 – Totals O/U 47
Packers Spread -7, Winner -348
Cowboys Spread +7, Winner +251
Sep 29 – Totals O/U 45
Jets Spread +3, Winner +131
Dolphins Spread -3, Winner -168
Sep 29 – Totals O/U 44
Bengals Spread +7, Winner +281
Broncos Spread -7, Winner -388
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About the Author
Since 2008, D.S. Williamson has written about sports and sports handicapping. His philosophy is value-based, meaning stats and other handicapping factors are only worth something in comparison to wagering odds. He believes money management and making value-based wagers is the single more important factor that distinguishes successful sports bettors from non-successful sports bettors.
