2025 Buffalo Bills Betting

Ready to make the most of your Betting Buffalo Bills picks? We provide all the tools you need, from Bills lines to the latest Bills odds, helping you stay ahead of the competition. Whether you’re looking to bet against the spread or explore other betting opportunities, we’ve got you covered with in-depth analysis. Don’t forget to check out the 1st half and 2nd half betting lines, along with NFL props on each game, for more chances to maximize your bets. Stay informed with our detailed breakdowns of every Buffalo Bills matchup to make the smartest wagering decisions.

Who are the Buffalo Bills?

American Football League | Eastern Division
Highmark Stadium

The Buffalo Bills are an American professional football team based in the Buffalo–Niagara Falls metropolitan area and competes in NFL as a member of the American Football League Eastern Division.

Founded in 1960 as one of the eight original members of the American Football League (AFL), the Bills quickly established themselves as contenders by winning back-to-back AFL championships in 1964 and 1965 with starting quarterback Jack Kemp. Following the merger of the AFL and NFL in 1970, the Bills continued their success, becoming a fixture in the playoffs throughout the 1970s and 1980s.

The name "Buffalo Bills" was inspired by the famous frontiersman William Frederick "Buffalo Bill" Cody, the owners wanted a name that reflected the strength, tenacity and pioneering spirit of the city of Buffalo and its people.

The Bills, with their passionate fan base known as the "Bills Mafia," are determined to rewrite their recent history and compete for a championship.

The Buffalo Bills, with four consecutive Super Bowl appearances in the early 1990s, but without winning a championship have etched their place in NFL history as a team of unwavering spirit and perseverance. Now, with their storied past marked by triumphs and heartaches, as well as a passionate fan base, the Buffalo Bills are looking to recapture their glory days in the upcoming season.

Best Bills Games to Bet On During the Season | Look Out for these Games

If we are going to talk about the Bills top games to bet on, it has to be their rivalry matches during the season. So for that, we have to talk about their NFL rivals, the Bills have a couple of key rivals that guarantee must-bet games, offering a variety of betting opportunities:

Bills Patriots Rivalry

The Bills’ rivalry with the Patriots have always been a betting bonanza, you know that you are getting into an explosive mix of quarterbacks and offenses that will only ensure high-scoring affairs, so lock in those Bills Patriots betting lines as these matches have playoff implications that are often on the line. Analyzing the past seasons, potential upsets can lead to a strategic moneyline bet on the Bills to reclaim AFC East dominance.

Sunshine Showdown: Bills Dolphins Rivalry

The Phins’ recent resurgence has intensified this rivalry which offers a fascinating contrast. Look after the Bills Dolphins betting lines as this evolving rivalry offers a unique opportunity for those strategic bettors that are after that hidden value based on coaching schemes and roster matchups.

So place your bets and get ready to witness the Buffalo Bills take on their toughest adversaries yet!

Buffalo Bills Odds | MyBookie Buffalo Lines

Bet the latest NFL daily lines for the Bills, AFC East standings, plus betting news on the Bills. Remember, MyBookie has the Football odds along with 1st half lines for each game through out the Regular Season and Postseason reaching all the way to the next Super Bowl.

Betting Odds for the Bills

Moneyline, point spread, game totals for Straight Bets, Parlays, Teasers, and If Bets for the full game, 1st half bets, 2nd half bets, quarter bets and live betting. Plus all NFL props for each Bills games through out the NFL season.

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Buffalo Bills News | Recent NFL History, Rumors, & Betting Analysis

Bills fans, ignite the passionate flames of the Bills Mafia with the latest betting news! Get insider access to team stats, expert analysis on upcoming games plus futures odds for the Bills’ Super Bowl run.

Don’t miss your chance to make your winning pick and join the Bills betting frenzy!